Contact informationPlease contact Francesca Micci for more information
The aim of this project “Molecular cytogenetic characterization of new cancer-specific chromosome abnormalities” is to investigate by molecular cytogentics techniques a number of cancer-specific chromosome abnormalities that have hitherto been unknown or whose consequences for other reasons have not yet been established.
The abnormality to be put under scrutiny have partly been detected during the regular diagnostic cancer cytogenetic service our section provides nation-wide, partly they have been found as a result of research-motivated cytogenetic screening programs of different tumor types. By studing the molecular correlates of these cancer-specific chromosomal rearrangements in ever greater detail, we gain information about the pathogenetic mechanisms that are operative in these particular tumors and tumor types.
Planned examination of new cancer-specific chromosomal abnormalities
Identification of the additional material of unknown origin sitting on chromosome 19 (short and/or long arm) in ovarian carcinomas:
The project is in part completed which has led to the publication of the following article:
- Micci F, Weimer J, Haugom L, Skotheim RI, Grunewald R, Abeler VM, Silins I, Lothe RA, Trope CG, Arnold N, Heim S. Reverse painting of microdissected chromosome 19 markers in ovarian carcinoma identifies a complex rearrangement map. Genes Chromosome and Cancer 2009 48(2):184-93.
Molecular characterization of 6p rearrangements in endometrial stromal sarcoma:
The project is in part completed which has led to the following publications:
- Micci F, Walter CU, Teixeira MR, Panagopoulos I, Bjerkehagen B, Sæter G, Heim S. 2003. Cytogenetics and molecular genetic analyses of endometrial stromal sarcoma: non random involvement of chromosome arms 6p and 7p and confirmation of JAZF1/JJAZ1 gene fusion in t(7;17). Cancer Genetics and Cytogenetics 144:119-124.
- Micci F, Panagopoulos I, Bjerkehagen B, Heim S. 2006. Consistent rearrangement of chromosoma band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma. Cancer Res 66:107-12.br/>Micci F, Heim S. Pathogenetic Mechanisms in Endometrial Stromal Sarcoma. Cytogenetics and Genome Research 118(2-4):190-5
B-cell malignancies with t(14;19)(q32;p13):
The project is completed leading to the article:
- Micci F, Panagopoulos I, Tjønnfjord GE, Kolstad A, Delabie J, Beiske K, Heim S. 2007. Molecular cytogenetic characterization of t(14;19)(q32;p13), a new recurrent translocation in B-cell malignancies. Virchows Archiv 450(5):559-65
Atypical chronic myeloid leukemia with t(3;21)(q21;q22):
The project is completed and has led to the publication of the following article:
- Micci F, Panagopoulos I, Haugom L, Andersen HK, Tjønnfjord GE, Beiske K, Heim S t(3;21)(q22;q22) Leading to Truncation of the RYK Gene in Atypical Chronic Myeloid Leukemia. Cancer Letters 2009 (in press).