Håvard E. Greger Danielsen

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Prostate Cancer Candidate Genes

Many genes are involved in the development and progression of prostate cancer. We have identified 52 candidate genes that we suspect play a critical role in prostate cancer. The gene products are being analyzed using immunohistochemistry on a learning set comprised of patients with very clear prognosis, and the most promising genes will be analyzed on the entire available prostate material. We have developed software (ImmunoPath) to analyze IHC specimens; hence the work is now automated and efficient.

The candidate genes are also analyzed on the mRNA level using NanoString technology, and the clinically meaningful genes will also be located in the chromatin using FISH, and hence related to the Nucleotyping results. These analyses complement the big picture of hetero­geneity in prostate cancer, and will provide valuable information in the future clinical context.

This text was last modified: 01.02.2016

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Chief Editor: Prof. Håvard E. Danielsen
Copyright Oslo University Hospital. Visiting address: The Norwegian Radium Hospital, Ullernchausséen 64, Oslo. Tel: 22 78 23 20