PhD Candidates at the ICGI
Andreas Kleppe is a joint PhD-candidate within the Department of Informatics at the University of Oslo. His background is in mathematics, statistics, programming and image analysis. Over the past five years, he has worked at the ICGI developing and testing new methods for distinguishing cancer patients with increased risk of relapse after surgery. These methods are based on automatic analysis of chromatin organization in cancer nuclei, through analysis of the texture of light microscope images of nuclei with DNA-specific staining. Further work will make the analysis as general and specific as possible, and relate the findings to the fundamental biological conditions.
Jørn Jacobsen will, in 2017, finish his PhD work with the title “Cost effectiveness analysis of different options for management for early stage localized prostate (ESLPCa) cancer in a Norwegian health care setting.” The project utilizes the theories of health economics to analyze cost, patient experience and treatment efficacy around different modalities of prostate cancer treatment. This will give valuable insight into how the chosen treatment affects economical aspects both for the patient and society as a whole. The project is in collaboration with Vestfold Hospital and London School of Hygiene and Tropical Medicine.
Elin Ersvær commenced her degree in 2012 and will finish in 2017. She identifies biomarkers for prostate cancer using techniques like DNA ploidy, FISH, Nucleotyping and immunohistochemistry. Further, her work investigates heterogeneity in prostate cancer and metastases.
Karolina Cyll came to the ICGI as a MSc student in 2011, where her project entailed reviewing and increasing the efficiency of the ploidy preparation lab procedure. In 2013 she commenced a PhD degree with the title “High-resolution, high-throughput nuclear analysis as a prognostic marker in prostate cancer.” The study is dedicated finding prognostic markers for patients with early and intermediate stage of prostate cancer. Investigated material comprises of formalin-fixed paraffin-embedded prostate tumor tissue from radical prostatectomies as well as biopsy materials from patients under surveillance. The main focus is genomic instability, resistance to cell death and immortality of cancer cells. The employed methods are DNA ploidy, nucleotyping, immunohistochemistry and FISH. In addition, she is involved in projects investigating tumor heterogeneity in prostate cancer, and aids in 3D reconstruction of prostatic tumors visualizing tumor architecture and regional distribution of prostate cancer biomarkers. She will finish her degree in 2018.
Synne Torkildsen is a hematologist at Oslo University Hospital and commenced her PhD in 2014. The goal of her project is to identify and characterize new fusion genes in hematological neoplasia.
Antonio Agostini spent a year as an exchange researcher before starting a PhD-program in 2015. He will now contribute to increase our understanding of ovarian cancer and in particular look at which genetic rearrangements are behind the tumorigenesis and/or tumor progression of the ovarian epithelium. The title of his project is “Integrated genomic characterization of ovarian cancer”.
Ole Johan Skrede is a joint PhD-candidate within the Department of Informatics at the University of Oslo, and is since 2015 part of the MEDIMA project. His work focuses on finding methods for automatic 2D cell nuclei segmentation in colorectal cancer specimens, using artificial neural networks. He will further aim to reconstruct 3D volumes from stacks of 2D histology slices, allowing segmentation of nuclei in three dimentions. He will finish his degree in 2019.